This song is about a relationship between a man and a woman who has a mental disorder. Manic depressive or borderline personality. Likely platonic at he outset. However, both of them are all right with it. It is not about suicide. Byrne does not write about suicide. When she 'jumps out the window she is up. Floating in the mist means she is down. And she likes the curious feeling. The first part is about him. the next part is about her. "c'mon, Im up. Im down" "Im not lost but I don;t know where I am" means she is down a the moment not sure of what she is thinking. But it is no trouble at all. She can come and go as she pleases in the man's life. Now the topic changes to love. He is love with her but "hey man, I sure dont feel the same". It is unrequited. "Did I get a big surprise". And the song ends with a constant repeating of "uh oh". W hat have I done? Where do we go from here?; The song does not drift out to nothing. A perfect ending. '