# Angiotensin ii stimulates Na+/H+ exchangers located on the apical membranes (faces the tubular lumen) of cells in the proximal tubule and thick ascending limb of the loop of Henle in addition to Na+ channels in the collecting ducts. This will ultimately lead to increased sodium reabsorption
# Angiotensin ii stimulates the hypertrophy of renal tubule cells, leading to further sodium reabsorption.
He renin-angiotensin system is predominantly a sodium-losing system, as angiotensin ii has little or no effect on aldosterone levels. Renin levels are high in the fetus, while angiotensin ii levels are significantly lower; this is due to the limited pulmonary blood flow, preventing ace (found predominantly in the pulmonary circulation) from having its maximum effect.