This song is about gerard and mikey way's grandmother who died during the making of the band's second cd "three cheers for sweet revenge". Gerard and mikey were both very attached to their grandmother. Despite Gerard and Mikey's Grandmother's name is Elena, the song dedicated to her is called "Helena". This is because her friends called her Helen, so the two names together (Helen+ Elena) form the title of the song. Also whilst filming the video for "Helena" Gerard had to leave the room after watching Tracy (the woman acting as Gerard and Mikey's grandmother) dancing because it was to emotional. Mikey cried the first time he heard the song.