Possible religious meaning. They could be saying, as in Get Born Again, that Christ is still dead (possibly also the man in the box), or that we are the man in the box hoping that someone (ie, a religious figure) will save us from the horror of knowing that death and decomposition is the end.
"Jesus Christ/Deny your maker/He who tries will be wasted" could be a reference to the idea that you can't fight the fact that your fate is sealed (as in the box). We're all going to die, and you can't fight that fact. Fatalism, basically. As in, either there is no maker, or, the maker set up the system that says we die. There's no changing it either way.
Or, it could mean that Jesus Christ should have denied his maker, because he according to aic wasn't resurrected, and wound up just as dead as all of us will be? Who knows.
Either way, basically, the uplifting message: sarcasm: is that yes, the underdog who gets beat and kicked around, will not be saved or rescued, and will still wind up six feet below (or are already boxed in, even during life). Wow. With a worldview like that, no wonder addiction was the perceived only way out for the lead singer?